Epidemiology, microbiology, and diagnosis of infection in diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: A multicenter retrospective observational study
Authors' conclusion
The mortality rate was higher in patients with bacteremia than patients without it. CRP, rather than PCT, may be valid for diagnosing bacteremia in hyperglycemic emergencies.
Study context
- Population
- Adult hospitalized patients with diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic syndrome (HHS), 21 acute-care hospitals in Japan; mean age 58.2 (SD, 19.3) years545 DKA, 226 HHS
- Participants
- 771 participants
- Exposure
- C-reactive protein (CRP) vs procalcitonin (PCT) for diagnosis of bacteremia
- Outcome
- Diagnostic accuracy of inflammatory markers (CRP, PCT) for bacteremia
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Diagnosis of bacteremia
| Group | AUC |
|---|---|
| CRP | 0.85 (95 %CI, 0.81-0.89) |
| PCT | 0.76 (95 %CI, 0.60-0.92) |
AUC
CRP0.85 (95 %CI, 0.81-0.89)
PCT0.76 (95 %CI, 0.60-0.92)
Observational data: associations, not effects.
Further findings
Mortality, with vs without bacteremia
P < 0.001
Positive blood culture
- Tested positive for blood culture
- 70
Risk factors for bacteremia (logistic regression)
- Older age, altered level of consciousness, hypotension and higher CRP identified as risk factors for bacteremia
Original publication
Epidemiology, microbiology, and diagnosis of infection in diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: A multicenter retrospective observational study. Diabetes Res Clin Pract. Published 19 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →