Incidence and Predictors of Acute Pancreatitis in Patients With Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS): A Multicenter Retrospective Study
Authors' conclusion
AP occurs in a substantial proportion of hyperglycemic crises. Its development is linked to specific metabolic and hemodynamic stressors, suggesting a multifactorial pathophysiology.
Study context
- Population
- Patients with hyperglycemic crisis (DKA/HHS per ADA criteria) at 3 tertiary hospitals, January 2015–August 2025; Acute pancreatitis (AP) per revised Atlanta criteria
- Participants
- 406 patients
- Exposure
- DKA vs HHS
- DKAn = 303
- HHSn = 103reference
- Outcome
- Incidence of acute pancreatitis (AP)
Methodological detailsmulticentre, 3 tertiary hospitals
- Multicentre
- 3 tertiary hospitals
Main finding
As reported in the abstract
Incidence of AP
- Developed AP, total cohort
- 60 (14.8%)
Observational data: associations, not effects.
Further findings
Independent predictors of AP, total cohort (multivariable)
- Higher BMI, abdominal pain, shock, elevated γ-GTP and hypertriglyceridemia independently predicted AP
Independent predictors of AP, DKA subgroup
- Alcohol consumption, T2D, abdominal pain, shock and γ-GTP were independent predictors
Presentation with vs without AP
- Patients with AP more often had abdominal pain and shock, and higher serum γ-GTP and TG
Clinical outcomes with AP
- AP associated with increased ICU admission, but not increased hospital stay or in-hospital mortality
Original publication
Incidence and Predictors of Acute Pancreatitis in Patients With Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS): A Multicenter Retrospective Study. Endocr Pract. Published 28 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →