A UK nationwide study of adults admitted to hospital with diabetic ketoacidosis or hyperosmolar hyperglycaemic state and COVID ‐19
Authors' conclusion
Hospitalization with COVID-19 and adjudicated DKA is four times more common than HHS but both associate with substantial mortality. There is a strong association of previous insulin therapy with survival in type 2 diabetes-associated DKA.
Study context
- Population
- Adults hospitalized with COVID-19 and diabetes (211 T1D, 3748 T2D, 114 unknown type), Association of British Clinical Diabetologists nationwide audit, start of pandemic to November 2021hospitalized with COVID-19
- Participants
- 4,073 adults
- Exposure
- Diabetic ketoacidosis (DKA) vs hyperosmolar hyperglycaemic state (HHS) in adults hospitalized with COVID-19
- DKAn = 85
- HHSn = 20reference
- Outcome
- Inpatient mortality
Methodological detailsnationwide audit, anonymized data
- Nationwide audit
- Anonymized data
Main finding
As reported in the abstract
P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Age-adjusted OR (95% CI) | |
|---|---|---|
| Mortality in T2D with DKA: insulin usersvs non-users | 0.13 (0.03–0.60) | |
| 0.050.21520Age-adjusted OR (log scale) |
Age
P < 0.001
Non-White ethnicity
P = 0.038
| Outcome | P value |
|---|---|
| Crude mortality: statin users vs non-usersNot statistically significant after age adjustment | P = 0.035 |
- Mortality in DKA by diabetes type: T2D 36.8% · n = 57
- Mortality in DKA by diabetes type: T1D 3.8% · n = 26
- Mortality in T2D with DKA: insulin users vs non-users: Insulin users 21.4%
- Mortality in T2D with DKA: insulin users vs non-users: Non-users 52.2%
- Crude mortality: statin users vs non-users: Statin users 36.4%
- Crude mortality: statin users vs non-users: Non-users 100%
Original publication
A UK nationwide study of adults admitted to hospital with diabetic ketoacidosis or hyperosmolar hyperglycaemic state and COVID ‐19. Diabetes Obes Metab. Published 25 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →