Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome
Authors' conclusion
Obesity, aging, and amyloid burden relate to systemic inflammation in adults with DS. Obesity showed the strongest and most consistent associations
Study context
- Population
- Nondemented adults with Down syndrome (DS) in the Alzheimer Biomarkers Consortium-DS (ABC-DS)
- Participants
- 188 adults
- Outcome
- Associations of BMI, age and PET-measured amyloid burden with plasma inflammatory biomarkers
Methodological detailsmixed linear models, adjusted for sex, trisomy type and collection site, false discovery rate correction
- Mixed linear models
- Adjusted for sex, trisomy type and collection site
- False discovery rate correction
Main finding
As reported in the abstract
Plasma inflammatory biomarkers
- Higher BMI associated with elevated CRP, IL-6, TNF-α, B2M, IL-18 and slCAM-1
- p < 0.05
- Older age associated with higher B2M
- β = 1.22e + 05, p < 0.001
- Amyloid burden positively associated with IL-6
- β = 0.005, p = 0.037
Observational data: associations, not effects.
Further findings
- The majority of participants met criteria for obesity
Original publication
Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome. Obesity (Silver Spring). Published 5 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →