Selected biomarkers of coagulation, inflammation, and vascular tone in young women with normal weight obesity
Authors' conclusion
Young women with NWO exhibit subclinical endothelial dysfunction, which is characterized primarily by a pro-thrombotic state and disturbed angio-inflammatory balance. These changes occur even before the onset of overt metabolic or cardiovascular disease.
Study context
- Population
- Young women (median age 20) with normal Body Mass Index (BMI) (18.5–24.9 kg/m²)
- Participants
- 176 women
- Exposure
- Normal Weight Obesity (NWO) vs normal-weight controls
- NWOn = 88
- NWn = 88reference
- Outcome
- Serum endothelial dysfunction biomarkers (tPA, vWF, Ang-1, NO, hs-CRP)
Main finding
As reported in the abstract
tPA, vWF and Ang-1
| Group | Value | Von Willebrand factor (vWF) (ng/ml) | Ang-1 (pg/ml) |
|---|---|---|---|
| NWO | 1.86 ng/ml | 72.24 | 515.3 |
| NW | 1.48 ng/ml | 63.62 | 491.63 |
Value
NWO1.86 ng/ml
NW1.48 ng/ml
Von Willebrand factor (vWF) (ng/ml)
NWO72.24
NW63.62
Ang-1 (pg/ml)
NWO515.3
NW491.63
- NWO vs NW: P = 0.038
- NWO vs NW: P = 0.038
- NWO vs NW: P = 0.008
Observational data: associations, not effects.
Further findings
Principal component analysis of endothelial biomarkers
- Three components (Coagulation: tPA, vWF; Inflammation/Angiogenesis: High-sensitivity C-reactive protein (hs-CRP), Ang-1; Vasodilation: Nitric Oxide (NO)) explained total variance
- 71.68%
Original publication
Selected biomarkers of coagulation, inflammation, and vascular tone in young women with normal weight obesity. Int J Obes (Lond). Published 4 August 2026. doi:10.
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