Increased risk of renal events in people with diabetic foot disease: A longitudinal observational study
Authors' conclusion
The risk of renal events was increased in people with T2DM and DFD.
Study context
- Population
- Patients hospitalized for T2D between 2009 and 2017, followed until December 2020
- Participants
- 519 patients
- Exposure
- Diabetic foot disease (DFD) and at risk vs no risk
- DFDn = 142
- At riskn = 159
- Outcome
- New renal events:
- End-stage renal disease
- Doubling of serum creatinine
- Follow-up
- 54 ± 27 months
Methodological detailslongitudinal observational, multivariable Cox regression
- Longitudinal observational
- Multivariable Cox regression
Main finding
As reported in the abstract
New renal events
Hazard ratio
2.7 to 5.9
DFD
Hazard ratio
2.8 to 5.1
At risk
DFD
15
events
At risk
15
events
Grade 0
6
events
- Logrank test across groups
- P = 0.001
- Total renal events
- 36
Observational data: associations, not effects.
Further findings
Type of renal event
- Started dialysis
- 19
- Renal transplantation
- 1
- Doubling of serum creatinine
- 16
Original publication
Increased risk of renal events in people with diabetic foot disease: A longitudinal observational study. Diabetes Metab. Published 1 May 2024. doi:10.
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