Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China
Main finding · Stroke (pooled)Result — go to the resultPooled adjusted hazard ratio 0.79 95% CI 0.69–0.92Authors' conclusion
Maintaining a healthy lifestyle was associated with a lower risk of stroke, IS and ICH among individuals with diabetes.
Study context
- Population
- Individuals with diabetes in China, from the Comprehensive Research on the Prevention and Control of the Diabetes (CRPCD) project (15,191) and the China Kadoorie Biobank (CKB) study (26,123)CRPCD 2,499 · CKB 4,578
- Participants
- 41,314 individuals2 cohorts
- Exposure
- ≥5 healthy lifestyle factors vs ≤2 HLS
- Outcome
- Stroke
- Follow-up
- Median 8.02 (CRPCD) and 9.05 (CKB) years
Methodological detailstwo prospective cohorts (CRPCD and CKB), Cox proportional hazard models
- Two prospective cohorts (CRPCD and CKB)
- Cox proportional hazard models
Main finding
Stroke (pooled)
Pooled adjusted hazard ratio
0.79
95% CI 0.69–0.92
≥5 HLSvs ≤2 HLS
pooled adjusted HR 0.79 (95% CI 0.69–0.92)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Stroke, CRPCD cohort14% lower risk | HR 0.86 (95% CI 0.75–0.98) | |
| Stroke, IS and ICH, CKB cohort≥5 HLSvs ≤2 HLS | adjusted HR (stroke) 0.74 (95% CI 0.66–0.83) | |
| Stroke, IS and ICH, CKB cohort≥5 HLSvs ≤2 HLS | adjusted HR (IS) 0.74 (95% CI 0.66–0.83) | |
| Stroke, IS and ICH, CKB cohort≥5 HLSvs ≤2 HLS | adjusted HR (ICH) 0.57 (95% CI 0.42–0.78) | |
| IS and ICH (pooled)≥5 HLSvs ≤2 HLS | pooled adjusted HR (IS) 0.80 (95% CI 0.68–0.93) | |
| IS and ICH (pooled)≥5 HLSvs ≤2 HLS | pooled adjusted HR (ICH) 0.60 (95% CI 0.46–0.78) | |
| 0.512Ratio (log scale) |
Cases documented (CRPCD and CKB, respectively)
- Stroke
- 2499 and 4578
- Ischaemic stroke (IS)
- 2147 and 4024
- Intracerebral haemorrhage (ICH)
- 160 and 728
Original publication
Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China. Diabetes Obes Metab. Published 29 April 2024. doi:10.
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