Effect of proteinuria on the rapid kidney function decline in chronic kidney disease depends on the underlying disease: A post hoc analysis of the BRIGHTEN study
Authors' conclusion
The risk of rapid kidney function decline in NS-DM patients with low levels of proteinuria may be greater than initially predicted.
Study context
- Population
- CKD patients who participated in the BRIGHTEN study
- Participants
- 1,038 patients
- Comparison
- Diabetic kidney disease (DKD) vs NDKD+DM vs NS-DM
- Primary endpoint
- Rapid kidney function decline (eGFR loss of > 5 mL/min/1.73 m²/year), annual eGFR decline estimated by linear mixed effect model
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
Prevalence of rapid decliners
Further findings
Prevalence of rapid decliners by UPCR category (<0.5, 0.5 to < 1.0, 1.0 to < 3.5, and ≥ 3.5 g/g)
- Equivalent between DKD and NS-DM in each UPCR category
UPCR < 1.0 g/g among rapid decliners
- Prevalence in NS-DM more than double that in DKD and NDKD+DM
Original publication
Effect of proteinuria on the rapid kidney function decline in chronic kidney disease depends on the underlying disease: A post hoc analysis of the BRIGHTEN study. Diabetes Res Clin Pract. Published 26 April 2024. doi:10.
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