Long-term Cumulative Incidence of Clinically Diagnosed Retinopathy in the Finnish Diabetes Prevention Study
Primary result · Cumulative incidence of clinically diagnosed DRResult — go to the resultOdds ratio 1.15 95% CI 0.61–2.21Authors' conclusion
A higher cumulative HbA1c was significantly associated with a higher risk of retinopathy. No evidence was found for a beneficial effect of a 4-year lifestyle intervention on the long-term occurrence of clinical DR during a median of 22-year follow-up.
Study context
- Population
- Individuals with impaired glucose tolerance (IGT) from the Finnish Diabetes Prevention Study (DPS), mean age 55 (range 40–64 years) at study onset
- Participants
- 505 individuals
- Comparison
- Lifestyle intervention vs usual care control
- Interventionn = 257
- Controln = 248reference
- Primary endpoint
- Cumulative incidence of clinically diagnosed diabetic retinopathy (DR)
- Follow-up
- Median 22 years
Methodological detailsmedian 22-year follow-up, national hospital register outcome ascertainment, Retinopathy diagnoses from the Finnish national hospital Care Register for Health
- Median 22-year follow-up
- National hospital register outcome ascertainment
- Retinopathy diagnoses from the Finnish national hospital Care Register for Health
Primary result
As reported in the abstract
median 22-year follow-up
Odds ratio
1.15
95% CI 0.61–2.21
Events by treatment group
Interventionvs Control
OR 1.15 (95% CI 0.61–2.21)
Further findings
| Outcome | Developed diabetes | No diabetes | OR (95% CI) | |
|---|---|---|---|---|
| Retinopathy diagnosis: developed diabetes during follow-upvs notAdjusted for group, age, sex; not statistically significant | 33/349 events | 9/156 events | 1.86 (0.89–4.28) | |
| 0.20.5125Odds ratio (log scale) |
Higher cumulative hemoglobin A1c (HbA1c) and risk of retinopathy
- HR for retinopathy with higher cumulative HbA1c (95% posterior interval 1.02-1.88; adjusted for group, age, sex)
- 1.4
- Significant association
Original publication
Long-term Cumulative Incidence of Clinically Diagnosed Retinopathy in the Finnish Diabetes Prevention Study. J Clin Endocrinol Metab. Published 25 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →