Compromised cardiac autonomic function in non-diabetic subjects with 1 h post-load hyperglycemia: a cross-sectional study
Authors' conclusion
Subjects with 1hPG ≥ 155 mg/dl have an impaired cardiac autonomic function.
Study context
- Population
- Non-diabetic subjects subdivided by oral glucose tolerance test (OGTT) data
- Participants
- 88 subjects
- Exposure
- Normal glucose tolerance (NGT) 1 h-high and impaired glucose tolerance (IGT) vs NGT 1 h-low
- Outcome
- Cardiac autonomic neuropathy (CAN) by cardiovascular autonomic reflex tests (CARTs) and heart rate variability (HRV) by 24-h ECG
Main finding
As reported in the abstract
- Vs NGT 1 h-low, NGT 1 h-high and IGT more likely to have cardiovascular autonomic reflex tests (CARTs)-defined cardiac autonomic neuropathy (CAN) and reduced SDNN, SDANN, RMSSD, PNN50 and Triangular index
Observational data: associations, not effects.
Further findings
Association of glucose levels with heart rate variability (HRV) and CAN (univariate)
- 1hPG, but not fasting and 2hPG, inversely associated with all HRV parameters and positively with CARTs-determined CAN
Multivariate regression
- 1hPG an independent contributor of HRV and presence of CAN
Original publication
Compromised cardiac autonomic function in non-diabetic subjects with 1 h post-load hyperglycemia: a cross-sectional study. Cardiovasc Diabetol. Published 10 August 2024. doi:10.
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