A Comparison of the Rates of Clock-Based Nocturnal Hypoglycemia and Hypoglycemia While Asleep Among People Living with Diabetes: Findings from the Hypo-METRICS Study
Authors' conclusion
Using 00:00 to 06:00 as a proxy for sleeping hours may underestimate hypoglycemia while asleep.
Study context
- Population
- Adults with T1D or insulin-treated T2D; 47% T1D, 45% women, 89% white, median age 56 (IQR 45–66) years, HbA1c 7.3% (6.8–8.0)
- Participants
- 574 adults
- Comparison
- Hypoglycemia while asleep vs clock-based nocturnal hypoglycemia
- Primary endpoint
- Weekly rates of sensor-detected (SDH) and person-reported hypoglycemia (PRH) while asleep vs clock-based nocturnal
- Follow-up
- 10 weeks
Methodological detailspaired comparison, blinded CGM, Fitbit-defined sleep intervals
- Paired comparison
- Blinded CGM
- Fitbit-defined sleep intervals
Primary result
As reported in the abstract
Median weekly rate of SDH <70 mg/dL, T1D
While asleep
1.7
median
Nocturnal
1.4
median
P < 0.001
Further findings
| Outcome | While asleep | Nocturnal | P value |
|---|---|---|---|
| Weekly rate of SDH <70 mg/dL, T2DHigher while asleep | 0.8 | 0.7 | P < 0.001 |
Weekly rate of sensor-detected hypoglycemia (SDH) <70 mg/dL, T2D
- Higher weekly rates of SDH while asleep than nocturnal SDH in T2D
Sleep duration
- Median sleep duration
- 6.1 h (5.2-6.8)
- Bedtime and waking time
- ∼23:30 and 07:30
Original publication
A Comparison of the Rates of Clock-Based Nocturnal Hypoglycemia and Hypoglycemia While Asleep Among People Living with Diabetes: Findings from the Hypo-METRICS Study. Diabetes Technol Ther. Published 17 April 2024. doi:10.
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