Impact of high intensity physical activity compared to routine counseling on renal function decline in patients with type 2 diabetes at high risk for kidney disease - the ACTIDIANE randomized controlled trial
Authors' conclusion
In pT2D with rapid renal function decline, HIPA did not significantly alter renal function decline compared to STPA.
Study context
- Population
- Patients with T2D and rapid renal function decline (eGFR slope < −5 ml/min/year over 6–24 months), 21 centres; mean age 66 ± 8 years103 analysed
- Participants
- 122 patients
- Comparison
- High-intensity physical activity (PA) vs standard PA counseling
- High-intensity PA (HIPA)n = 59
- STPAn = 44reference
- Primary endpoint
- Slope of decline in cystatin C-derived eGFR (cys-eGFR)
- Follow-up
- Two years
Methodological detailsopen, multicentre
- Open
- Multicentre
Primary result
As reported in the abstract
cys-eGFR slope
HIPA
−2.05
95% CI −3.46–-0.64 · ml/min/year
STPA
−2.77
95% CI −4.40–-1.14 · ml/min/year
P = 0.512
Further findings
Cardiovascular events and deaths
P = 0.646
- Cardiovascular events and deaths — Deaths in HIPA (none protocol-related)
- 3
Safety
Events
| Outcome | HIPA | STPA | P value |
|---|---|---|---|
| Hypoglycaemia | 32 | 26 | P = 0.623 |
Original publication
Impact of high intensity physical activity compared to routine counseling on renal function decline in patients with type 2 diabetes at high risk for kidney disease - the ACTIDIANE randomized controlled trial. Diabetes Metab. Published 23 May 2026. doi:10.
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