ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
Authors' conclusion
Our study strongly suggests that lysine lactylation and ACSF2 are mediators of mitochondrial dysfunction and may contribute to the progression of diabetic nephropathy.
Study context
- Population
- Renal biopsy samples, First Affiliated Hospital of Zhengzhou University; kidney tissues from db/db and db/m mice; human proximal tubular epithelial cells (HK-2)
- Comparison
- Diabetic nephropathy vs controls without diabetes and kidney disease; db/db vs db/m mice
- Diabetic nephropathyn = 22
- Controln = 9reference
- Outcome
- Lysine lactylation and ACSF2 in diabetic kidneys
Main finding
As reported in the abstract
- Lactylome db/db vs db/m: upregulated proteins
- 165
- Lactylome db/db vs db/m: downregulated proteins
- 17
- Increased lysine lactylation sites
- 356
- Decreased lysine lactylation sites
- 22
- Most lactylated proteins in mitochondria
- 115 proteins, 269 sites
Original publication
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes. Diabetologia. Published 27 April 2024. doi:10.
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