Diabetic foot disease carries an intrinsic high risk of mortality and other severe outcomes in type 2 diabetes: a propensity score-matched retrospective population-based study
Authors' conclusion
Although DFD often coexists with other risk factors, it carries an intrinsic high risk of morbidity and mortality in individuals with T2DM. DFD should be regarded as a severe complication already at its onset, as it carries a poor clinical prognosis.
Study context
- Population
- Individuals with T2D from primary-care settings; first diabetic foot disease (DFD) episode 2010–2015, followed up until 2018matched cohort
- Exposure
- DFD vs no DFD
- DFDn = 11,117
- Outcome
- Incidence of fatal and non-fatal events
- Follow-up
- Until 2018
Methodological detailspropensity score matched 1 to 1, primary-care settings
- Propensity score matched 1 to 1
- Primary-care settings
Main finding
As reported in the abstract
Composite outcome:
- All-cause mortality
- CV events
Observational data: associations, not effects.
Further findings
| Outcome | DFD | Without DFD | HR (95% CI) | |
|---|---|---|---|---|
| New DFD episode | 22.2 IR per 100 person-years | 1.1 IR per 100 person-years | 15.1 (13.8–16.5) | |
| Amputation | 19.4 (16.7–22.6) | |||
| 0.050.21520Hazard ratio (log scale) |
Original publication
Diabetic foot disease carries an intrinsic high risk of mortality and other severe outcomes in type 2 diabetes: a propensity score-matched retrospective population-based study. Cardiovasc Diabetol. Published 19 June 2024. doi:10.
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