Association of podocyte ultrastructural changes with proteinuria and pathological classification in type 2 diabetic nephropathy
Authors' conclusion
Podocyte injury, characterized by FPW broadening and PD, was associated with the severity of proteinuria and the pathological classification of DN.
Study context
- Population
- Patients with kidney biopsy-confirmed T2DN, Peking University First Hospital, 2017–2022
- Participants
- 110 patients
- Exposure
- Podocyte ultrastructure (foot process width (FPW), podocyte detachment (PD)) by proteinuria severity and Renal Pathology Society (RPS) pathological classification
- Outcome
- Mean podocyte foot process width (FPW) by proteinuria severity
Methodological detailssingle-centre, kidney biopsy-confirmed, morphometric analysis
- Single-centre
- Kidney biopsy-confirmed
- Morphometric analysis
Main finding
As reported in the abstract
- FPW cut-off >506 nm differentiating nephrotic from non-nephrotic proteinuria: sensitivity
- 75.3%
- FPW cut-off >506 nm differentiating nephrotic from non-nephrotic proteinuria: specificity
- 75.8%
- Correlation of FPW with proteinuria
- r = 0.473, p < 0.001
Observational data: associations, not effects.
Further findings
Percentage of podocyte detachment (PD) by proteinuria severity
- Percentage of podocyte detachment (PD) by proteinuria severity — Correlation of PD with proteinuria
- r = 0.656, P < 0.001
Percentage of podocyte detachment (PD) by proteinuria severity
- PD significantly higher with nephrotic proteinuria than microalbuminuria or overt proteinuria
FPW and PD vs RPS pathological classification of diabetic nephropathy (DN)
- Correlation of FPW with RPS classification
- r = 0.179, P = 0.014
- Correlation of PD with RPS classification
- r = 0.250, P = 0.001
- FPW increased with more severe DN classification
- P for trend = 0.007
- PD tended to increase with more severe DN classification
- P for trend = 0.017
Original publication
Association of podocyte ultrastructural changes with proteinuria and pathological classification in type 2 diabetic nephropathy. Diabetes Metab. Published 7 June 2024. doi:10.
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