Impact of severe hypoglycaemia requiring hospitalization on mortality in people with type 1 diabetes: A national retrospective observational cohort study
Authors' conclusion
The strongest predictor for time to death was having two or more episodes of severe hypoglycaemia requiring hospitalization.
Study context
- Population
- People with T1D diagnosed between 2000 and 2018 in Wales
- Participants
- 8,224 people
- Exposure
- No, one, two and three or more episodes of severe hypoglycaemia requiring hospitalization
- Outcome
- All-cause mortality
Methodological detailsnational, observational
- National
- Observational
Main finding
As reported in the abstract
All-cause mortality rate (deaths/1000 person-years), crude and age-adjusted
| Group | Value | Age-adjusted rate |
|---|---|---|
| No episodes | 6.9 (95% CI 6.1–7.8) deaths/ 1000 person-years (crude) | 15.31 (13.3-17.63) |
| One episode | 24.9 (95% CI 21.0–29.6) deaths/ 1000 person-years (crude) | 53.8 (44.6-64.7) |
| Two episodes | 28.0 (95% CI 23.1–34.0) deaths/ 1000 person-years (crude) | 72.8 (59.2-89.5) |
| Three or more episodes | 33.5 (95% CI 30.0–37.3) deaths/ 1000 person-years (crude) | 86.3 (71.7-103.9) |
Value
No episodes6.9 (95% CI 6.1–7.8) deaths/ 1000 person-years (crude)
One episode24.9 (95% CI 21.0–29.6) deaths/ 1000 person-years (crude)
Two episodes28.0 (95% CI 23.1–34.0) deaths/ 1000 person-years (crude)
Three or more episodes33.5 (95% CI 30.0–37.3) deaths/ 1000 person-years (crude)
Age-adjusted rate
No episodes15.31 (13.3-17.63)
One episode53.8 (44.6-64.7)
Two episodes72.8 (59.2-89.5)
Three or more episodes86.3 (71.7-103.9)
- No episodes: P < 0.001 — across episode categories (age-adjusted)
Observational data: associations, not effects.
Further findings
Predictors of time to death (parametric survival model)
- Two episodes, accelerated failure time coefficient (95% CI) — strongest predictor
- 0.073 [0.009-0.565]
- One episode, accelerated failure time coefficient
- 0.126 [0.036-0.438] (95% CI)
- Age at most recent episode, accelerated failure time coefficient
- 0.917 [0.885-0.951] (95% CI)
Original publication
Impact of severe hypoglycaemia requiring hospitalization on mortality in people with type 1 diabetes: A national retrospective observational cohort study. Diabetes Obes Metab. Published 4 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →