Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia
Authors' conclusion
Hypoglycaemia can still lead to proarrhythmogenic electrocardiographic changes in individuals with T1D and IAH. We observed diurnal, inter- and intraindividual variability in responses to hypoglycaemia.
Study context
- Population
- Adults with T1D and impaired awareness of hypoglycaemia (IAH); mean (SD) age 39 (10) years, T1D duration 24 (9) years, 10/14 female10/14 female
- Participants
- 14 adults
- Exposure
- Hypoglycaemia vs time and person-matched euglycaemia
- Outcome
- QTc interval
- Follow-up
- Daytime
Methodological details96 h ambulatory ECG with blinded continuous interstitial glucose (IG) monitoring, time and person-matched euglycaemia comparison, historical control group
- 96 h ambulatory ECG with blinded continuous IG monitoring
- Time and person-matched euglycaemia comparison
- Historical control group
Main finding
As reported in the abstract
P = 0.027
Observational data: associations, not effects.
Further findings
Tpeak-to-Tend interval · daytime
P = 0.002
Mean
| Outcome | Hypoglycaemia | Euglycaemia | P value |
|---|---|---|---|
| T wave area symmetry · daytime | 1.19 (SD 0.37) | 1.39 (SD 0.23) | P = 0.014 |
| High-frequency power (HRV) · daytime | 1.66 (SD 0.41) | 1.92 (SD 0.52) | P = 0.038 |
- Tpeak-to-Tend change (hypoglycaemia vs euglycaemia), IAH vs historical controls without IAH · daytime · decreased significantly more in IAH
- p for interaction 0.005
Safety
- Cardiac arrhythmias were infrequent and of no clinical significance
Original publication
Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia. Diabet Med. Published 27 February 2025. doi:10.
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