Association between recent exposure to continuous glucose monitoring‐recorded hypoglycaemia and counterregulatory and symptom responses to subsequent controlled hypoglycaemia in people with type 1 diabetes
Authors' conclusion
Recent exposure to CGM-detected hypoglycaemia was independently associated with an attenuated adrenaline response to experimental hypoglycaemia in people with type 1 diabetes.
Study context
- Population
- People with T1D (20 females; mean ± SD HbA1c 7.8% ± 1.0%; diabetes duration median 22.0 (IQR 10.5–34.9) years; 29 continuous glucose monitoring (CGM) users; 19 with impaired awareness of hypoglycaemia); HypoRESOLVE project
- Participants
- 42 people
- Comparison
- Association of antecedent CGM-recorded hypoglycaemia with counterregulatory and symptom responses to experimental hypoglycaemia
- Outcome
- Counterregulatory hormone and symptom responses to standardized hyperinsulinaemic-hypoglycaemic [2.8 ± 0.1 mmol/L (50.2 ± 2.3 mg/dl)] clamp
Methodological detailshyperinsulinaemic-hypoglycaemic glucose clamp, 1-week open isCGM
- Hyperinsulinaemic-hypoglycaemic glucose clamp
- 1-week open isCGM
Main finding
As reported in the abstract
Adrenaline response vs CGM-recorded hypoglycaemia in prior week
CGM-recorded hypoglycaemia negatively associated with adrenaline response, β (95% CI) nmol/L, p
−0.09
−0.16, −0.02p = .014
Level 2 hypoglycaemia [<3.0 mmol/L (54 mg/dl)] and adrenaline response, β (95% CI) nmol/L, p
−0.21
−0.41, −0.01p = .034
Further findings
Total, autonomic and neuroglycopenic symptom responses
- Negatively associated with CGM-recorded hypoglycaemia, but associations lost after adjusting for potential confounders
Original publication
Association between recent exposure to continuous glucose monitoring‐recorded hypoglycaemia and counterregulatory and symptom responses to subsequent controlled hypoglycaemia in people with type 1 diabetes. Diabetes Obes Metab. Published 22 May 2024. doi:10.
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