Rebound Hypoglycemia and Hyperglycemia in Type 1 Diabetes
Authors' conclusion
The strong correlation between Rhyper and Rhypo suggests an individual behavioral characteristic toward intensive correction of glucose excursions.
Study context
- Population
- Persons with T1D using isCGM; 90 days of data
- Participants
- 159 persons
- Outcome
- Rebound hypoglycemia (Rhypo) and rebound hyperglycemia (Rhyper) events
- Follow-up
- 90 days
Main finding
As reported in the abstract
90 days
- Hypoglycemic events identified
- 10 977
- Rebound hypoglycemia (Rhypo)
- 3232 (29%)
- Rebound hyperglycemia (Rhyper)
- 3653 (33%)
- Median frequency, hypoglycemic events / Rhypo / Rhyper per person/14 days
- 10.1, 2.5, and 3.0
- Rhypo and Rhyper coexisted
- 1267 (12%)
- Mean peak glucose before Rhypo
- 13.0 ± 1.6 mmol/l
- Mean peak glucose in Rhyper
- 12.8 ± 1.1 mmol/l
Observational data: associations, not effects.
Further findings
Correlation of Rhyper frequency with other glycemic metrics (Spearman's rho)
- Rhyper vs Rhypo (P < .001)
- 0.84
- Rhyper vs glucose CV (P < .001)
- 0.78
- Rhyper vs TBR (P < .001)
- 0.69
- Rhyper vs TAR, not significant (P = .13)
- 0.12
Original publication
Rebound Hypoglycemia and Hyperglycemia in Type 1 Diabetes. J Diabetes Sci Technol. Published 3 May 2023. doi:10.
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