Hypo‐ and hyperglycaemia following pancreas transplantation for people with type 1 diabetes
Authors' conclusion
Recipients with post-transplantation hypoglycaemia were more likely to be women and of low body weight, which may be due to disordered eating with restricted calorie or carbohydrate intake. Recipients with post-transplantation hyperglycaemia had features of insulin resistance and type 2 diabetes with increased weight and men predominance. Glycaemic disturbance was not associated with graft failure
Study context
- Population
- People with T1D with a functioning pancreas transplant and glucose tolerance test (GTT) data, University Hospital Wales, January 2013 to April 2019
- Participants
- 96 people
- Exposure
- Hypoglycaemia vs hyperglycaemia vs normoglycaemia after pancreas transplantation
- Outcome
- Rates of glycaemic disturbance
Methodological detailsroutinely collected data, single-centre
- Routinely collected data
- Single-centre
Main finding
As reported in the abstract
Glycaemic disturbance
- Developed glycaemic disturbance
- 30%
Observational data: associations, not effects.
Further findings
Mean, kg/m²
| Outcome | Hypoglycaemia | Hyperglycaemia | Normoglycaemia | Difference (kg/m²) (CI) | P value | |
|---|---|---|---|---|---|---|
| BMIHyperglycaemiavs Hypoglycaemia | 23.7 | 27.6 | — not stated in the abstract | 3.89 (0.77–7.0) | P = 0.017 | |
| −50510Difference, kg/m² (linear scale) |
— not stated in the abstract
Graft failure — Hypoglycaemia vs Normoglycaemia · across all three groups
P = 0.70
| Outcome | Hypoglycaemia | Hyperglycaemia | Normoglycaemia | P value |
|---|---|---|---|---|
| WomenHypoglycaemia vs Hyperglycaemia | 90% | 26% | — not stated in the abstract | P = 0.001 |
— not stated in the abstract
Graft failure
- No increase in graft failure with glycaemic disturbance
Original publication
Hypo‐ and hyperglycaemia following pancreas transplantation for people with type 1 diabetes. Diabet Med. Published 7 April 2026. doi:10.
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