The impact of prior exposure to hypoglycaemia on the inflammatory response to a subsequent hypoglycaemic episode
Authors' conclusion
Hypoglycaemia induces an acute and persistent pro-inflammatory response at multiple levels that occurs largely, but not completely, independent of prior exposure to hypoglycaemia. Clinical Trial information
Study context
- Population
- Healthy participants; hyperinsulinaemic hypoglycaemic (2.8 ± 0.1 mmol/L) glucose clamp on day 2
- Participants
- 32 participants
- Comparison
- Antecedent hypoglycaemia vs normoglycaemia on day 1, before a hypoglycaemic clamp on day 2
Primary result
As reported in the abstract
Adrenaline response to next-day hypoglycaemia
Further findings
Inflammatory responses to day 2 hypoglycaemia · up to 1 week
- Circulating inflammatory proteins, incl. hs-CRP, increased for up to 1 week
- 19
- In both groups, hypoglycaemia increased absolute circulating immune cells; lymphocytes and monocytes remained elevated for the whole week
- Proportion of pro-inflammatory CD16+-monocytes increased during hypoglycaemia
- After ex vivo stimulation, monocytes released more TNF-α and IL-1β and less IL-10 in response to hypoglycaemia
- Most inflammatory responses similar in the two groups; persistent pro-inflammatory protein changes partly blunted with antecedent hypoglycaemia
- No correlation between adrenaline response and inflammatory responses during hypoglycaemia
Original publication
The impact of prior exposure to hypoglycaemia on the inflammatory response to a subsequent hypoglycaemic episode. Cardiovasc Diabetol. Published 8 February 2024. doi:10.
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