Association between recent real‐life exposure to hypoglycaemia and cognitive function during hypoglycaemia in people with type 1 diabetes: Findings from the Hypo‐ RESOLVE clamp study
Authors' conclusion
Our findings indicate that recent real-life CGM-recorded hypoglycaemia is not associated with cognitive decline during clamped hypoglycaemia in people with type 1 diabetes. This suggests that cognitive decline during hypoglycaemia is not susceptible to habituation.
Study context
- Population
- People with T1D given open isCGM (Freestyle Libre 1®) for a week before a hypoglycaemic clamp (2.8 ± 0.1 mmol/L)
- Participants
- 42 people
- Comparison
- Recent real-life continuous glucose monitoring (CGM)-recorded hypoglycaemia exposure vs cognitive decline during clamped hypoglycaemia
- Outcome
- Association between recent real-life CGM-recorded hypoglycaemia and changes in cognitive function (Paced Auditory Serial Addition Test (PASAT); TAP-Alertness, Verbal Flexibility, Working Memory) during clamped hypoglycaemia
Methodological detailshyperinsulinaemic-euglycaemic-hypoglycaemic clamp
- Hyperinsulinaemic-euglycaemic-hypoglycaemic clamp
Main finding
As reported in the abstract
Association of prior CGM-recorded hypoglycaemia with cognitive change during clamp
- No associations between prior CGM-recorded hypoglycaemia and changes in cognitive function during the clamp
- Adjusted for sex, age, diabetes duration, HbA1c and hypoglycaemia awareness status (linear regression)
Further findings
Hypoglycaemia exposure (glucose <3.9 mmol/L) in the week before the clamp
- Average events/week
- 5.8 (3.1-8.8)
Cognitive function during clamped hypoglycaemia vs baseline
- Cognitive function declined for all tests
- all p < 0.01
Original publication
Association between recent real‐life exposure to hypoglycaemia and cognitive function during hypoglycaemia in people with type 1 diabetes: Findings from the Hypo‐ RESOLVE clamp study. Diabetes Obes Metab. Published 11 July 2025. doi:10.
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