Sustained Hemoglobin A1c (HbA1c) Improvements Over 36 Months in Youth in the Teamwork, Targets, Technology, and Tight Control (4T) Study
Main finding · HbA1cResult — go to the resultAdjusted difference 1.2 % 95% CI 0.7%–1.7%Authors' conclusion
Youth with T1D in the Pilot 4T extension phase sustained improvements in HbA1c over 3 years. Focusing resources on intensive management during the first year after T1D diagnosis may impact long-term glycemia.
Study context
- Population
- Youth with T1D in the Pilot 4T Study, Stanford Medicine Children's Health Diabetes Clinic78.5% of Pilot 4T cohort
- Participants
- 102 participants
- Exposure
- Pilot 4T cohort vs Historical cohort
- Pilot 4Tn = 102
- Outcome
- Change in HbA1c
- Follow-up
- 3 years
Methodological detailsextension phase, historical controls, single-centre
- Extension phase
- Historical controls
- Single-centre
Main finding
HbA1c
Adjusted difference
1.2 %
95% CI 0.7%–1.7%
Pilot 4Tvs Historical
adjusted difference 1.2 % (95% CI 0.7%–1.7%)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Met HbA1c target <7.5% · 3 years
Met HbA1c target <7% · 3 years
Original publication
Sustained HbA1c Improvements Over 36 Months in Youth in the Teamwork, Targets, Technology, and Tight Control (4T) Study. J Clin Endocrinol Metab. Published 10 July 2025. doi:10.
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