Real‐life hypoglycaemia partially blunts the inflammatory response to experimental hypoglycaemia in people with type 1 diabetes
Authors' conclusion
Repeated exposure to spontaneous hypoglycaemia is associated with blunted effects of subsequent experimental hypoglycaemia on circulating immune cells and the number of inflammatory proteins.
Study context
- Population
- People with T1D; glucose monitored 1 week before the clamp with Freestyle Libre 1
- Participants
- 40 people
- Primary endpoint
- Relationship between frequency and duration of spontaneous hypoglycaemia and TBR, and the inflammatory response to experimental hypoglycaemia
Primary result
As reported in the abstract
- Hypoglycaemia episodes per day (average)
- 0.79 (0.43, 1.14)
- Duration of hypoglycaemia episodes (minutes)
- 78 (47, 110)
- Time below range (TBR)
- 5.5% (2.8%, 8.5%)
- TBR and hypoglycaemia frequency inversely associated with increase in circulating granulocyte and lymphocyte counts during experimental hypoglycaemia
- P < .05 for all
- Protein network (DNER, IF-R, uPA, Flt3L, FGF-5, TWEAK) negatively associated with hypoglycaemia frequency, but not with adrenaline response
- P < .05
Original publication
Real‐life hypoglycaemia partially blunts the inflammatory response to experimental hypoglycaemia in people with type 1 diabetes. Diabetes Obes Metab. Published 20 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →