Association of KLF14 rs4731702 gene polymorphism with metabolic phenotype in young patients with type 1 diabetes
Authors' conclusion
Our study suggests that the T allele of the KLF14 rs4731702 SNP might confer a protective effect against the development of obesity, hypertension, dyslipidaemia, and chronic inflammatory state in patients diagnosed with T1D.
Study context
- Population
- Young patients with T1D and healthy control subjects350 T1D, 250 controls
- Comparison
- KLF14 rs4731702 T allele carriers vs C allele carriers in T1D
- Outcome
- Association of KLF14 rs4731702 polymorphism with metabolic syndrome traits (inflammatory markers, blood pressure, lipid profile, CD4+CD25highFOXP3+ T cells)
Methodological detailscase-control
- Case-control
Main finding
As reported in the abstract
Metabolic syndrome traits by KLF14 rs4731702 allele in T1D
- T allele carriers had higher HDL-C, lower LDL-C, lower HbA1c and lower proinflammatory markers than C allele carriers
- T allele carriers developed hypertension less often than C allele carriers
- TT genotype had the highest frequency of CD4+CD25highFOXP3+ regulatory T cells vs CC and CT genotypes
Observational data: associations, not effects.
Original publication
Association of KLF14 rs4731702 gene polymorphism with metabolic phenotype in young patients with type 1 diabetes. Diabetes Obes Metab. Published 18 June 2024. doi:10.
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