Determinants of vascular impairment in type 1 diabetes–impact of sex and connexin 37 gene polymorphism: A cross-sectional study
Authors' conclusion
In addition to known information, easily obtainable risk factor, such as pulse pressure, should be considered in individuals with T1D irrespective of sex and genetic background. The associations of plasma lipids with kidney function are complex and associated with sex and genetic factors. The decision of whether pulse pressure, remnant lipoproteins, Lp(a) and other determinants of vascular damage should become treatment targets in T1D should be based on the results of future clinical trials.
Study context
- Population
- Individuals with T1D younger than 65 years; mean age 43.6 ± 13.6 years, mean diabetes duration 22.1 ± 11.3 years235 men · 227 women
- Outcome
- Associations of cardiovascular risk factors with vascular and renal parameters (multivariate regression)
Main finding
As reported in the abstract
- Pulse pressure strongly associated with unfavourable values of most vascular parameters (ankle brachial index (ABI), toe brachial index (TBI), Belcaro scores, urine albumin/creatinine ratio (uACR), Oliva-Roztocil index (ORI))
- Remnant cholesterol, atherogenic index of plasma and Lp(a) associated primarily with renal impairment (uACR, glomerular filtration rate (GFR))
- Non-HDL cholesterol not associated with any vascular parameter
- Unlike pulse pressure, associations of lipid factors with kidney and vascular parameters modified by sex and Cx37 gene
Observational data: associations, not effects.
Original publication
Determinants of vascular impairment in type 1 diabetes–impact of sex and connexin 37 gene polymorphism: A cross-sectional study. Cardiovasc Diabetol. Published 22 August 2024. doi:10.
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