Hypoglycaemia induces a sustained pro‐inflammatory response in people with type 1 diabetes and healthy controls
Authors' conclusion
Overall, despite differences in prior exposure to hypoglycaemia, the pattern of the inflammatory responses to hypoglycaemia did not differ between people with type 1 diabetes and healthy controls. In conclusion, hypoglycaemia induces a range of pro-inflammatory responses that are sustained for at least 1 week in people with type 1 diabetes and healthy controls.
Study context
- Population
- Adults with T1D and matched controls undergoing a hyperinsulinaemic-euglycaemic hypoglycaemic (2.8 ± 0.1 mmoL/L) glucose clamp
- Participants
- 47 vs 16
- Comparison
- Hypoglycaemia in T1D vs matched healthy controls
- T1Dn = 47
- Controlsn = 16reference
- Outcome
- Duration and extension of the pro-inflammatory response to hypoglycaemia (immune cell phenotype, monocyte function, circulating inflammatory markers)
- Follow-up
- Euglycaemia, hypoglycaemia, and 1, 3 and 7 days later
Methodological detailshyperinsulinaemic-euglycaemic hypoglycaemic glucose clamp, matched controls
- Hyperinsulinaemic-euglycaemic hypoglycaemic glucose clamp
- Matched controls
Main finding
As reported in the abstract
Pro-inflammatory response to hypoglycaemia
- Circulating inflammatory proteins increased by hypoglycaemia, incl. hs-CRP, most remaining elevated for 1 week
- 19
Original publication
Hypoglycaemia induces a sustained pro‐inflammatory response in people with type 1 diabetes and healthy controls. Diabetes Obes Metab. Published 24 July 2023. doi:10.
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