Sustained heart rate‐corrected QT prolongation during recovery from hypoglycaemia in people with type 1 diabetes, independently of recovery to hyperglycaemia or euglycaemia
Authors' conclusion
In people with type 1 diabetes, insulin-induced hypoglycaemia prolongs cardiac repolarization, which is sustained during a 60-minute recovery period independently of recovery to hyperglycaemia or euglycaemia. Thus, vulnerability to serious cardiac arrhythmias and sudden cardiac death may extend beyond a hypoglycaemic event, regardless of hyperglycaemic or euglycaemic recovery.
Study context
- Population
- People with T1D undergoing clamps with euglycaemic phase, 60-minute insulin-induced hypoglycaemic phase (2.5 mmol/L) and recovery, during ECG monitoring
- Participants
- 24 people
- Comparison
- Recovery in hyperglycaemia vs euglycaemia after insulin-induced hypoglycaemia
- Primary endpoint
- Heart rate-corrected QT (QTc)
Methodological detailsexperimental clamps
- Experimental clamps
Primary result
As reported in the abstract
QTc interval
Peak QTc >500 ms during hypoglycaemia
63% of participants
Further findings
Markers of arrhythmic risk and vagal tone · hypoglycaemia
- All measured markers of arrhythmic risk indicated increased risk during hypoglycaemia, with decreased vagal tone in both clamps
Heart-rate variability · recovery
- No change from baseline in heart-rate variability measures during recovery
Original publication
Sustained heart rate‐corrected QT prolongation during recovery from hypoglycaemia in people with type 1 diabetes, independently of recovery to hyperglycaemia or euglycaemia. Diabetes Obes Metab. Published 20 February 2023. doi:10.
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