Acute brain responses to hypoglycaemia and hyperglycaemia in adolescents with type 1 diabetes
Authors' conclusion
Across widespread areas of the brain, both brain perfusion and neural metabolic activity are altered by acute hypoglycaemia and hyperglycaemia in adolescents with type 1 diabetes. Recovery from glycaemic extremes is delayed. These findings offer important further insights into the acute cerebral responses to abnormal blood glucose levels.
Study context
- Population
- Adolescents with T1D
- Participants
- 20 adolescents
- Exposure
- Induced hypoglycaemia or hyperglycaemia vs baseline euglycaemia, and euglycaemic recovery
- Hypoglycaemian = 10
- Hyperglycaemian = 10
- Outcome
- Regional differences in CBF (arterial spin labelling) and brain neural activity (fractional amplitude of low frequency fluctuations) across 7 cortical functional networks between glycaemic phases
Methodological detailsparallel study arms, Bayesian multi-level regression model
- Parallel study arms
- Bayesian multi-level regression model
Main finding
As reported in the abstract
Hypoglycaemia: substantially reduced brain neural activity
6 of 7 functional networks
Hyperglycaemia: widespread increases in brain activity
5 of 7 functional networks
Hyperglycaemia: decreased perfusion
6 of 7 functional networks
Observational data: associations, not effects.
Further findings
Euglycaemic recovery · >45 min of sustained euglycaemia
- Persistent alterations in brain perfusion and neural activity vs baseline after recovery from both hypo- and hyperglycaemia
Original publication
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