Disease Duration and Chronic Complications Associate With Immune Activation in Individuals With Longstanding Type 1 Diabetes
Authors' conclusion
Disease duration and chronic complications associate with persistent alterations in the immune response of individuals with long standing T1D.
Study context
- Population
- People with longstanding T1D, Radboudumc, the Netherlands, recruited February 2016–June 2017
- Participants
- 243 people
- Outcome
- Associations of HbA1c, diabetes duration, insulin need and diabetes complications with immune cell phenotype and function and circulating inflammatory proteome (multivariate linear regression)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Clinical factors associated with immune dysregulation
- HbA1c positively associated with circulating inflammatory markers
- P < .05
- Diabetes duration associated with increased number of circulating immune cells
- P < .05
- Diabetes duration associated with inflammatory proteome
- P < .05
- Diabetes duration negatively associated with adaptive immune response against Mycobacterium tuberculosis and Rhizopus oryzae
- P < .05
- Diabetes nephropathy associated with increased circulating immune cells
- P < .05
- Diabetes nephropathy associated with increased inflammatory markers
- P < .05
Observational data: associations, not effects.
Original publication
Disease Duration and Chronic Complications Associate With Immune Activation in Individuals With Longstanding Type 1 Diabetes. J Clin Endocrinol Metab. Published 17 February 2023. doi:10.
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