Longitudinal Estimated Glomerular Filtration Rate Trajectories in Children with Type 1 Diabetes
Authors' conclusion
In conclusion, these data challenge the commonly held paradigm that renal function remains stable in childhood T1D
Study context
- Population
- Children aged ≤18 years with T1D, Diabetes Clinic, British Columbia Children's Hospital, Vancouver, Canada, recruited December 2016–February 2019; 54% male; median age at diagnosis 6.2 years, median T1D duration 6.9 years
- Participants
- 307 children
- Outcome
- Annualized eGFR trajectory (CKiD U25): declining (<−3), stable (−3 to +3), inclining (>+3) ml/min/1.73 m² per year
- Follow-up
- Median 2.3 years
Methodological detailsquality improvement initiative, single-centre
- Quality improvement initiative
- Single-centre
Main finding
As reported in the abstract
eGFR trajectories
Declining trajectory
33%
Stable trajectory
32%
Inclining trajectory
35%
Observational data: associations, not effects.
Further findings
Mildly decreased estimated glomerular filtration rate (eGFR), elevated BP (≥90th percentile) and/or abnormal urine albumin-creatinine ratio (≥2 mg/mmol) · during follow-up
- Any of these abnormalities
- 32%
- Referred for nephrology assessment
- <10%
eGFR <90
- Subjects with eGFR <90
- 23%
- More highly represented in the declining trajectory group (vs stable and inclining)
Factors associated with declining eGFR trajectory (logistic regression)
- Female sex and higher baseline eGFR associated with declining eGFR trajectory
Original publication
Longitudinal Estimated Glomerular Filtration Rate Trajectories in Children with Type 1 Diabetes. Pediatr Diabetes. Published 29 June 2023. doi:10.
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