Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications
Authors' conclusion
This study offers novel insights into long-term renal function trajectories in patients with HF and T2D and identifies key clinical factors associated with accelerated renal decline. Future research is warranted to validate these results in larger, more diverse cohorts and to explore potential therapeutic interventions.
Study context
- Population
- Ambulatory patients with heart failure (HF) and T2D referred to a specialized HF clinic; mean age 69.3 ± 10.3 years, 68.2% men10,830 creatinine measurements
- Participants
- 1,114 patients
- Primary endpoint
- Long-term eGFR trajectory (CKD-EPI), assessed at baseline and every three months
Methodological detailssingle specialized HF clinic, longitudinal, multivariable longitudinal Cox regression, Mean 15.8 ± 9.4 creatinine measurements per patient
- Single specialized HF clinic
- Longitudinal
- Multivariable longitudinal Cox regression
- Mean 15.8 ± 9.4 creatinine measurements per patient
Primary result
As reported in the abstract
Average annual rate of eGFR change
Significant progressive estimated glomerular filtration rate (eGFR) decline; average annual rate (95% CI - 2.11 to - 1.95, p < 0.001)
- 2.05 ml/min/1.73 m²
Further findings
Factors associated with eGFR decline (subgroup analysis)
- Older age, nonischaemic HF aetiology, HFpEF or HFmrEF, poor glycaemic control and higher baseline eGFR associated with more pronounced decline in renal function
All-cause mortality
- eGFR decrease independently associated with increased risk of all-cause mortality
Original publication
Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications. Cardiovasc Diabetol. Published 5 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →