Collagen turnover is associated with cardiovascular autonomic and peripheral neuropathy in type 1 diabetes: novel pathophysiological mechanism?
Authors' conclusion
Results show previously undescribed associations between markers of collagen turnover and risk of CAN and to a lesser degree DSPN in T1D.
Study context
- Population
- People with T1D; mean age 55.7 years, 51% males, diabetes duration 40.0 years
- Participants
- 300 people
- Outcome
- Association of markers of COL6 formation (PRO-C6) and COL3 degradation (C3M) with CAN (≥2 pathological cardiovascular reflex tests) and DSPN (vibration threshold >25 V)
Main finding
As reported in the abstract
Association of serum PRO-C6 and C3M with CAN and DSPN
Doubling of serum PRO-C6 associated with OR for cardiovascular autonomic neuropathy (CAN) (adjusted for relevant confounders)
> 2
Doubling of serum PRO-C6 associated with OR for distal symmetrical polyneuropathy (DSPN) (adjusted for relevant confounders)
> 1
Observational data: associations, not effects.
Further findings
Prevalence of CAN and DSPN
- CAN
- 34%
- DSPN
- 43%
Serum marker levels
Ng/ml
- Serum PRO-C6, median (IQR)
- 7.8 (6.2;11.0)
- Serum C3M, median (IQR)
- 8.3 (7.1;10.0)
Original publication
Collagen turnover is associated with cardiovascular autonomic and peripheral neuropathy in type 1 diabetes: novel pathophysiological mechanism? Cardiovasc Diabetol. Published 29 June 2023. doi:10.
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