Circulating metabolomic and lipidomic changes in subjects with new-onset type 1 diabetes after optimization of glycemic control
Authors' conclusion
Our data uncovered potential favorable changes in the metabolism of glycerophospholipids, glycerolipids, and sphingolipids in new-onset T1DM after achieving optimal glycemic control. Further research on their potential role in developing diabetes-related complications is needed.
Study context
- Population
- Adults with newly diagnosed T1D; mean age 25.2 years, 58.3 % men
- Participants
- 12 adults
- Exposure
- T1D at onset vs after achieving optimal glycaemic control
- Outcome
- Serum lipidomic and metabolomic changes
- Follow-up
- After 2-6 months
Methodological detailsmetabolomic and lipidomic analysis, before–after comparison
- Metabolomic and lipidomic analysis
- Before–after comparison
Main finding
As reported in the abstract
Identified lipids changed
51
Observational data: associations, not effects.
Further findings
HbA1c · after intensive therapy · decrease
P < 0.001
- Blood glucose · after intensive therapy · decrease
- P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Circulating metabolomic and lipidomic changes in subjects with new-onset type 1 diabetes after optimization of glycemic control. Diabetes Res Clin Pract. Published 16 February 2023. doi:10.
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