Glycemia Risk Index Assessment in a Pediatric and Adult Patient Cohort With Type 1 Diabetes Mellitus
Authors' conclusion
In pediatric patients and in those with CSII treatment, despite a better control by classical and GRI parameters, higher overall CHypo was observed than in adults and MDI, respectively. The present study supports the usefulness of the GRI as a new glucometric parameter to evaluate the global risk of hypoglycemia-hyperglycemia in both pediatric and adult patients with T1D.
Study context
- Population
- Patients with T1D on intensive insulin treatment (25.2% CSII) with isCGM, in clinical practice; 53% males, 67.8% adults, mean age 28.6 ± 15.7 years, 12.5 ± 10.9 years of T1D evolution
- Participants
- 202 patients
- Exposure
- Pediatric vs adult patients; CSII vs multiple doses of insulin (MDI)
- Outcome
- Glycemia risk index (GRI), with its hypoglycemia (component of hypoglycemia (CHypo)) and hyperglycemia (component of hyperglycemia (CHyper)) components
Main finding
As reported in the abstract
GRI
Pediatric
48.0
± 22.2
Adults
56.8
± 23.4
CSII
51.0
± 15.3
MDI
55.0
± 25.4
Pediatric vs Adults: P < 0.05 · CSII vs MDI: P = 0.162
Observational data: associations, not effects.
Further findings
| Outcome | Pediatric | Adults | CSII | MDI | P value |
|---|---|---|---|---|---|
| CHypoPediatric vs Adults | 7.1 ± 5.1 | 5.0 ± 4.5 | 6.5 ± 4.1 | 5.4 ± 5.0 | P < 0.01 |
| CHypoCSII vs MDI | P < 0.01 | ||||
| CHyperPediatric vs Adults | 16.8 ± 9.8 | 26.5 ± 15.1 | 19.6 ± 10.6 | 24.6 ± 15.2 | P < 0.01 |
| CHyperCSII vs MDI | P < 0.05 | ||||
| HbA1cAdults vs Pediatric · higher in adults | 6.7 ± 0.6 % | 7.4 ± 1.1 % | — not stated in the abstract | — not stated in the abstract | P < 0.01 |
| TIRAdults vs Pediatric · lower in adults | 66.5 ± 13.1 % | 55.4 ± 17.5 % | — not stated in the abstract | — not stated in the abstract | P < 0.01 |
| CVAdults vs Pediatric · lower in adults | 42.4 ± 8.9 % | 38.6 ± 7.2 % | — not stated in the abstract | — not stated in the abstract | P < 0.05 |
— not stated in the abstract
Original publication
Glycemia Risk Index Assessment in a Pediatric and Adult Patient Cohort With Type 1 Diabetes Mellitus. J Diabetes Sci Technol. Published 16 February 2023. doi:10.
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