Gut microbiome shifts in people with type 1 diabetes are associated with glycaemic control: an INNODIA study
Authors' conclusion
Our data revealed associations between the gut microbiome composition and the disease progression in individuals with recent-onset type 1 diabetes. Future mechanistic studies as well as animal studies and human trials are needed to further validate the significance and causality of these associations.
Study context
- Population
- People with newly diagnosed T1D followed 2 years and autoantibody-positive unaffected family members followed up to 36 months, INNODIA Natural History Study
- Participants
- 98 vs 194
- Exposure
- ND vs UFM
- NDn = 98
- UFMn = 194
- Outcome
- Gut microbiome composition and glycaemic control
Methodological detailssubgroup of the INNODIA Natural History Study, metagenomic sequencing, longitudinal
- Subgroup of the INNODIA Natural History Study
- Metagenomic sequencing
- Longitudinal
Main finding
As reported in the abstract
- Faecalibacterium prausnitzii relative abundance inversely associated with HbA1c at diagnosis
- p=0.0019
- 19 UFM individuals diagnosed with T1D had increased Sutterella sp. KLE1602 abundance vs undiagnosed UFM individuals
- p=1.2 × 10-4
Observational data: associations, not effects.
Original publication
Gut microbiome shifts in people with type 1 diabetes are associated with glycaemic control: an INNODIA study. Diabetologia. Published 4 June 2024. doi:10.
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