Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease
Authors' conclusion
The validated results reflect the landscape of biological changes accompanying type 1 diabetes. For example, the association of the targeted apolipoproteins with fasting C-peptide/glucose ratios in the first year after diagnosis is likely to relate to lipid abnormalities observed in individuals with type 1 diabetes, and reiterates the connection of apolipoproteins with the underlying changes accompanying the disease. Further research is needed to explore the clinical value and relevance of these targets.
Study context
- Population
- Individuals diagnosed with T1D under 18 years enrolled in the INNODIA study, and age- and sex-matched autoantibody-negative unaffected family members560 newly diagnosed (ND) samples
- Participants
- 146 vs 272
- Comparison
- Newly diagnosed youth with T1D vs autoantibody-negative unaffected family members (UFMs); protein levels vs fasting C-peptide/glucose ratio
- NDn = 146
- UFMsn = 272reference
- Outcome
- Validation of protein associations with fasting C-peptide/glucose ratio (proxy for beta cell function)
- Follow-up
- First year after diagnosis
Methodological detailslongitudinal cohort with cross-sectional comparison, targeted serum proteomics, selected reaction monitoring MS, longitudinal sampling, age- and sex-matched controls
- Longitudinal cohort with cross-sectional comparison
- Targeted serum proteomics
- Selected reaction monitoring MS
- Longitudinal sampling
- Age- and sex-matched controls
Performance
As reported in the abstract
Protein associations with fasting C-peptide/glucose ratio in ND
- Significant inverse associations with fasting C-peptide/glucose ratio confirmed for peptides from apolipoprotein B-100, apolipoprotein M and GPX3
- p<0.05
Further findings
- Consistent differences in levels of targeted proteins between T1D and UFMs (incl. GPX3, transthyretin, prothrombin, apolipoprotein C1, afamin)
- ten of the 13
Original publication
Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease. Diabetologia. Published 28 February 2025. doi:10.
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