Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory
Authors' conclusion
The association of several targeted proteins with fasting C-peptide/glucose levels in the first year after diagnosis suggests their connection with the underlying changes accompanying alterations in beta cell function in type 1 diabetes. Moreover, the direction of change in GPX3 during the first year was indicative of subsequent fasting C-peptide/glucose levels, and supports further investigation of this and other serum protein measurements in future studies of beta cell function in type 1 diabetes.
Study context
- Population
- Newly diagnosed youth (<18 years) with T1D, followed during the first year from diagnosis288 samples
- Participants
- 86 vs 194
- Exposure
- Youth with newly diagnosed T1D vs matched autoantibody-negative unaffected family members (UFMs)
- T1Dn = 86
- UFMsn = 194reference
- Outcome
- Associations of 85 T1D-associated serum proteins with fasting C-peptide/glucose (beta cell function)
- Follow-up
- First year after diagnosis
Methodological detailsselected reaction monitoring mass spectrometry, age- and sex-matched autoantibody-negative unaffected family member comparison
- Selected reaction monitoring mass spectrometry
- Age- and sex-matched autoantibody-negative unaffected family member comparison
Main finding
As reported in the abstract
Association of serum proteins with fasting C-peptide/glucose
- Proteins with statistically significant associations with fasting C-peptide/glucose
- 11
Observational data: associations, not effects.
Further findings
Protein levels in T1D vs matched UFMs
- Proteins differing between T1D and matched UFMs, incl. GPX3, transthyretin, prothrombin, apolipoprotein C1 and IGF family members
- 13
Original publication
Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory. Diabetologia. Published 4 August 2023. doi:10.
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