Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes
Authors' conclusion
T1D genetic risk delineates etiologic differences among KPD subgroups. Patients with A+β- KPD have the highest and those with A-β+ KPD the lowest GRS.
Study context
- Population
- Patients with ketosis-prone diabetes (54% Hispanic, 31% African American, 11% White)
- Participants
- 426 patients
- Exposure
- T1D genetic risk score across the four Aβ subgroups of ketosis-prone diabetes (KPD)
- Outcome
- T1D genetic risk score (GRS)
Main finding
As reported in the abstract
T1D GRS by KPD subgroup
- Rank order of genetic risk scores (GRS): A+β- > A+β+ = A-β- > A-β+
- GRS of A+β- KPD lower than a T1D cohort
- GRS of A-β+ KPD higher than a T2D cohort
Observational data: associations, not effects.
Further findings
GRS by race/ethnicity
- GRS lowest among African American patients, with a similar distribution across KPD subgroups
Original publication
Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes. Diabetes Care. Published 28 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →