Low‐density lipoprotein cholesterol in adolescents and young adults with type 1 diabetes: Data from the Australasian Diabetes Data Network registry
Authors' conclusion
LDL-C screening and levels are suboptimal in this cohort, increasing future cardiovascular complication risk. There is an urgent need to understand how healthcare services can support improved screening and management of dyslipidaemia in this population.
Study context
- Population
- Young people aged 16–25 years with T1D duration >1 year attending T1D healthcare visits, Australasian Diabetes Data Network (ADDN), January 2011–December 20201,603 with ≥1 low-density lipoprotein cholesterol (LDL-C)
- Participants
- 6,338 people
- Outcome
- Elevated LDL-C >2.6 mmol/L (100 mg/dL) and treatment threshold >3.4 mmol/L (130 mg/dL)
- Follow-up
- Last measurement
Methodological detailsprospective clinical quality registry, multivariable Generalised Estimated Equations (GEE)
- Prospective clinical quality registry
- Multivariable GEE
Main finding
As reported in the abstract
LDL-C at last measurement (among those with ≥1 LDL-C measurement)
Elevated LDL-C >2.6 mmol/L
737
46.0%
LDL-C at treatment threshold >3.4 mmol/L
250
15.6%
Observational data: associations, not effects.
Further findings
LDL-C screening: ≥1 LDL-C measurement documented
- ≥1 LDL-C measurement documented
- 1603 (25.3%)
Factors associated with elevated LDL-C (continuous), multivariable GEE
- Older age: OR = 0.07; 0.01-0.13, p = 0.02
- Female sex: OR = 0.31; 0.18-0.43; p < 0.001
- Higher HbA1c: OR = 0.04; 0.01-0.08; p = 0.01
- Elevated BMI: OR = 0.17, 0.06-0.39, p < 0.001
- Across all visits
Original publication
Low‐density lipoprotein cholesterol in adolescents and young adults with type 1 diabetes: Data from the Australasian Diabetes Data Network registry. Diabet Med. Published 27 July 2023. doi:10.
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