Comparative mortality and its determinants in community-based people with type 1 diabetes: the Fremantle Diabetes Study Phase I
Main finding · All-cause deathResult — go to the resultMRR 3.04 95% CI 2.13–4.31Authors' conclusion
T1D substantially increases the risk of death, especially when diagnosed in late adolescence/young adulthood. Diabetes type does not influence mortality after adjustment for key confounding variables.
Study context
- Population
- Community-based Australians with T1D, Fremantle Diabetes Study Phase I, entry 1993–1996, followed to death/end-2017; pooled mean±SD age 43.1±15.3 years, 59.2% men12,541 person-years
- Exposure
- T1D vs no diabetes
- T1Dn = 121
- Without diabetesn = 484reference
- Outcome
- All-cause mortality (mortality rates (MRs) and mortality rate ratios (MRRs))
- Follow-up
- Entry (1993-1996) to death/end-2017
Methodological detailscommunity-based, age/sex/postcode-matched
- Community-based
- Age/sex/postcode-matched
Main finding
All-cause death
MRR
3.04
95% CI 2.13–4.31
P < 0.001
Events by group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality, pooled Cox regression (T1D vs T2D)Adjusted | 1.18 (0.71–1.97) | P = 0.523 | |
| 0.512Hazard ratio (log scale) |
| Outcome | T1D | Without diabetes | T2D | MRR (95% CI) | P value |
|---|---|---|---|---|---|
| CVD deathT1D vs Without diabetes | 4.34 (2.43–7.73) | P < 0.001 | |||
| MR /1000 person-years | 11.7 (95% CI 7.6 to 17.3) | 2.7 (95% CI 1.8 to 3.9) | — not stated in the abstract | ||
| Death, T1D vs age/sex-matched T2D | 57.0% | — not stated in the abstract | 39.8% | P = 0.027 |
— not stated in the abstract
- Death, T1D vs age/sex-matched T2D: 93 matched pairs
Independent predictors of death in T1D
- Diagnosis at age 18-27 years and baseline HbA1c, urinary albumin:creatinine ratio and retinopathy were independent predictors of death
- P ≤ 0.011
Original publication
Comparative mortality and its determinants in community-based people with type 1 diabetes: the Fremantle Diabetes Study Phase I. BMJ Open Diabetes Res Care. Published 24 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →