Adherence to cardio-protective medications and cardiovascular disease in adults with type 1 diabetes
Authors' conclusion
In adults with type 1 diabetes, refill adherence of 50% or more to cardio-protective medications is associated with lower odds of incident CVD. Our findings highlight the relevance of going beyond prescribing protective CVD drugs, ensuring, and improving medication adherence matters.
Study context
- Population
- Adults with T1D who purchased AHT and/or lipid-lowering drugs within ± 0.5 year from baseline (Finnish Diabetic Nephropathy Study), followed until first cardiovascular disease (CVD) event, death, or end of 2015
- Participants
- 1,558 adults
- Exposure
- Good or intermediate vs poor refill adherence to AHT and/or lipid-lowering drugs
- Outcome
- CVD
- Follow-up
- Until first CVD event, death, or end of 2015
Main finding
As reported in the abstract
Each group vs poorOdds ratio (95% CI)P value
Good
0.55(0.33–0.92)
P = 0.02Intermediate
0.47(0.29–0.77)
P = 0.003Observational data: associations, not effects.
Further findings
Overall refill adherence (proportion of days covered (PDC))
- Median adherence rate (IQR 63-84 %)
- 74%
CVD per 10 unit increase in adherence, moderate albuminuria subgroup
- OR per 10 unit increase in adherence
- 0.81 (95% CI 0.67, 0.98; P=0.03)
Original publication
Adherence to cardio-protective medications and cardiovascular disease in adults with type 1 diabetes. Diabetes Res Clin Pract. Published 26 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →