Time With Rapid Change of Glucose
Authors' conclusion
TRC is proposed as an easily perceived metric to compare the performance of hybrid or fully automated closed-loop insulin delivery systems to obtain glucose homeostasis.
Study context
- Population
- Persons with T1D using Abbott Freestyle Libre version 1; glucose data for 90 days
- Participants
- 159 persons
- Outcome
- Time with rapid change of glucose (TRC): proportion of time (%) with absolute rate of change of glucose > 1.5 mmol/L/15 minutes (1.8mg/dL/min)
- Follow-up
- 90 days
Main finding
As reported in the abstract
TRC
- Median TRC (IQR 4.5%-9.5%)
- 6.9%
- TRC with positive slope
- 3.9% (2.6%-5.3%)
- TRC with negative slope
- 2.8% (1.5%-4.4%)
- Positive-slope TRC significantly higher than negative-slope TRC
- P < .001
- Spearman correlation of TRC with CVw
- .56
- Spearman correlation of TRC with mean amplitude of glycemic excursion (MAGE)
- .65
- P for correlations
- P < .001
Further findings
Distribution of glucose rates
- >1.27 million glucose rates, t-location scale distributed, SD (mmol/L/15 min)
- 0.91
Original publication
Time With Rapid Change of Glucose. J Diabetes Sci Technol. Published 2 June 2024. doi:10.
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