The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults
Authors' conclusion
In this large cohort with newly diagnosed type 1 diabetes, we identified age-related differences in clinical and biochemical variables. Of note, C-peptide was lower in younger children but there were no main age differences in its rate of decline.
Study context
- Population
- Individuals aged 1.0–45.0 years newly diagnosed with T1D, INNODIA cohort; 57.3% male; age 12.1±8.3 years; 96.9% positive for ≥1 diabetes-related antibody
- Participants
- 649 individuals
- Exposure
- Age at diagnosis: <10 years vs 10-17 years vs ≥18 years
- Outcome
- T1D heterogeneity (clinical characteristics, autoantibodies, beta cell function, glycaemic outcomes) and its relation to age at diagnosis
- Follow-up
- First 12 months from diagnosis
Methodological detailsnatural history study, multicentre European cohort, 3-monthly follow-up
- Natural history study
- Multicentre European cohort
- 3-monthly follow-up
Main finding
As reported in the abstract
baseline to 12 months
- Baseline fasting C-peptide, median (IQR)
- 242.0 (139.0-382.0) pmol/l
- Baseline C-peptide AUC, median (IQR)
- 749.3 [466.2-1106.1] pmol/l × min
- C-peptide levels increased with age
- p<0.001
Observational data: associations, not effects.
Further findings
Predictors of stimulated C-peptide over time
- Lower baseline fasting C-peptide, BMI SD score and DKA at diagnosis associated with lower stimulated C-peptide over time
Glycaemia, HbA1c and insulin requirement
- HbA1c decreased during the first 3 months
- P < 0.001
- Insulin requirement increased from 3 months post diagnosis
- P < 0.001
- Glucose levels progressively increased
Original publication
The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults. Diabetologia. Published 22 March 2024. doi:10.
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