Gestational diabetes & diabetes in pregnancy
Gestational Glucose Intolerance and Risk of Future Diabetes
Main finding · Incident diabetesResult — go to the resultAdjusted hazard ratio 2.01 95% CI 1.54–2.62Authors' conclusion
GGI confers an increased risk of future diabetes. Routinely available clinical data identify an unrecognized group who may benefit from enhanced diabetes screening and prevention.
Study context
- Population
- Individuals followed for prenatal and primary care16,836 individuals
- Participants
- 2,943 / 20,359 / 909
- Exposure
- Gestational glucose intolerance (GGI) vs normal glucose tolerance in pregnancy
- GGIn = 2,943
- Normal glucose tolerancen = 20,359reference
- Gestational diabetes mellitus (GDM)n = 909
- Outcome
- Incident diabetes
- Follow-up
- Median 8.4 years
Methodological detailsCox proportional hazards models with time-varying exposures and covariates
- Cox proportional hazards models with time-varying exposures and covariates
Main finding
As reported in the abstract
median 8.4 years
Adjusted hazard ratio
2.01
95% CI 1.54–2.62
P < 0.001
GGIvs Normal glucose tolerance
aHR 2.01 (95% CI 1.54–2.62); P < 0.001
- Individuals who developed diabetes
- 428
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | P value | |
|---|---|---|---|
| Incident diabetes by number of abnormal OGTT valuesZero abnormal OGTT valuesvs Normal glucose tolerance | 1.54 (1.09–2.16) | P = 0.01 | |
| Incident diabetes by number of abnormal OGTT valuesOne abnormal OGTT valuevs Normal glucose tolerance | 2.97 (2.07–4.27) | P < 0.001 | |
| Incident diabetes by number of abnormal OGTT valuesGDMvs Normal glucose tolerance | 8.26 (6.49–10.51) | P < 0.001 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
| Outcome | GGI | GDM |
|---|---|---|
| Fraction of diabetes cases attributable · 10 years after delivery | 8.5% | 28.1% |
Original publication
Gestational Glucose Intolerance and Risk of Future Diabetes. Diabetes Care. Published 21 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →