Gestational diabetes & diabetes in pregnancy
Maternal insulin resistance and maternal β‐cell function during pregnancy for offspring overweight before 2 years of age among women with gestational diabetes
Authors' conclusion
Both maternal increased insulin resistance and decreased β-cell function at diagnosis of GDM were associated with elevated risk of offspring overweight in early childhood among Chinese women with GDM.
Study context
- Population
- Offspring of Chinese women with gestational diabetes mellitus (GDM) enrolled in a lifestyle trial during pregnancy, followed to 24 months, Tianjin, China
- Participants
- 901 offspring
- Exposure
- Maternal high homeostatic model assessment of insulin resistance (HOMA-IR) and low HOMA-%β at GDM diagnosis
- Outcome
- Offspring overweight
- Follow-up
- Within 12 months and at 13-24 months of age
Methodological detailsoffspring follow-up of a lifestyle trial, restricted cubic spline analysis, logistic regression
- Offspring follow-up of a lifestyle trial
- Restricted cubic spline analysis
- Logistic regression
Main finding
As reported in the abstract
Odds ratio (95% CI)
High HOMA-IRoverweight within 12 months of age
1.71(1.12–2.62)
High HOMA-IRoverweight at 13-24 months of age
1.89(1.13–3.17)
Low HOMA-%βoverweight at 13-24 months of age
1.64(1.05–2.55)
Observational data: associations, not effects.
Original publication
Maternal insulin resistance and maternal β‐cell function during pregnancy for offspring overweight before 2 years of age among women with gestational diabetes. Pediatr Obes. Published 15 December 2022. doi:10.
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