Gestational diabetes & diabetes in pregnancy
Early-Pregnancy Serum Maternal and Placenta-Derived Exosomes Micro-RNAs (miRNAs) Vary Based on Pancreatic β-Cell Function in Gestational Diabetes Mellitus (GDM)
Authors' conclusion
Early serum exosomal miRNAs differ depending on their origin (maternal or placental) and pancreatic β-cell function. This research provides insights into the interactions between maternal and placental exosomal miRNAs and may have implications for identifying potential biomarkers or therapeutic targets for GDM.
Study context
- Population
- Pregnant women in early pregnancy (<18 weeks of gestation)
- Comparison
- Women who developed GDM vs normoglycemia, by pancreatic β-cell function
- Outcome
- Serum maternal and placenta-derived exosome miRNA profiles according to pancreatic β-cell function (HOMA-%β)
- Follow-up
- <18 weeks of gestation
Main finding
As reported in the abstract
Early-pregnancy serum maternal and placenta-derived exosomes and miRNAs
- Serum maternal exosome size and concentration modified in GDM and fluctuate according to HOMA-%β index
- Serum maternal exosomal hsa-miR-149-3p and hsa-miR-455-3p in GDM related to insulin secretion and signaling, lipolysis and adipocytokine signaling
- Placenta-derived exosomal hsa-miR-3665 and hsa-miR-6727-5p in GDM related to genes of immunological tolerance of pregnancy and pathways associated with placental dysfunction
Observational data: associations, not effects.
Original publication
Early-Pregnancy Serum Maternal and Placenta-Derived Exosomes miRNAs Vary Based on Pancreatic β-Cell Function in GDM. J Clin Endocrinol Metab. Published 21 December 2023. doi:10.
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