Gestational diabetes & diabetes in pregnancy
First‐trimester glycaemic markers as predictors of gestational diabetes and its associated adverse outcomes: A prospective cohort study
Authors' conclusion
Accelerated fetal growth is evident prior to the diagnosis of GDM. There remains a need for suitable methods of early identification of pregnancies at high risk for early accelerated fetal growth due to GDM. First-trimester HbA1c was not useful in identifying these pregnancies.
Study context
- Population
- Women at risk of gestational diabetes mellitus (GDM) by UK NICE risk factors, recruited at antenatal booking, major UK maternity unit; previous GDM excluded1,115 underwent OGTT
- Participants
- 1,243 women
- Exposure
- GDM vs non-GDM pregnancies
- GDMn = 236
- Outcome
- Prediction of excessive fetal growth by early pregnancy HbA1c
Methodological detailssingle maternity unit
- Single maternity unit
Main finding
As reported in the abstract
<14 weeks
P = <0.01
Observational data: associations, not effects.
Further findings
| Outcome | GDM | Non-GDM | P value |
|---|---|---|---|
| Adjusted fetal weight percentile · 28 weeks (at diagnosis) | 51.8 | 46.3 | P = 0.008 |
| Fetal abdominal circumference percentile · 28 weeks (at diagnosis) | 55.3 | 46.2 | P = <0.001 |
- Adjusted fetal weight percentile: 976 had fetal US
Original publication
First‐trimester glycaemic markers as predictors of gestational diabetes and its associated adverse outcomes: A prospective cohort study. Diabet Med. Published 12 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →