Gestational diabetes & diabetes in pregnancy
Roux-en-Y Gastric Bypass Increases Glycemic Excursions During Pregnancy and Postpartum: A Prospective Cohort Study
Authors' conclusion
Women with RYGB were more exposed to hypoglycemia and hyperglycemia during pregnancy compared with control participants. Further research should investigate whether hypoglycemia during pregnancy in women with RYGB is associated with decreased fetal growth.
Study context
- Population
- Pregnant women previously treated with RYGB and matched controls, CGM in first, second and third trimesters and 4 weeks postpartum
- Participants
- 23 vs 23
- Exposure
- Pregnant women with RYGB vs BMI- and parity-matched pregnant controls
- RYGBn = 23
- Controln = 23reference
- Outcome
- Interstitial glucose (IG) profiles during pregnancy; TIR defined as IG 3.5-7.8 mmol/L
- Follow-up
- First, second and third trimesters and 4 weeks postpartum
Methodological detailsBMI- and parity-matched controls, continuous glucose monitoring
- BMI- and parity-matched controls
- Continuous glucose monitoring
Main finding
As reported in the abstract
TIR · throughout pregnancy and postpartum
RYGB
87.3-89.5%
Control
93.3-96.1%
P < 0.01
Observational data: associations, not effects.
Further findings
Risk factors for increased time below range (TBR)
- Women with increased TBR had longer surgery-to-conception interval, lower nadir weight and greater weight loss after RYGB
TBR and SGA neonates
- Women giving birth to SGA neonates had slightly increased TBR
Original publication
Roux-en-Y Gastric Bypass Increases Glycemic Excursions During Pregnancy and Postpartum: A Prospective Cohort Study. Diabetes Care. Published 5 December 2022. doi:10.
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