Exercise ventilatory inefficiency may be a specific feature of patients with acromegaly
Authors' conclusion
Patients with acromegaly display ventilatory inefficiency during exercise. These findings suggest subclinical alveolar-capillary impairment or altered CO2 chemosensitivity. Exercise testing may help unmask these abnormalities, supporting its role in risk stratification and rehabilitation planning.
Study context
- Population
- Patients with controlled acromegaly; chronic diseases, cardio-respiratory conditions altering ventilatory response and cardiac dysfunction excluded
- Participants
- 10 vs 10
- Comparison
- Acromegaly vs matched controls
- Acromegalyn = 10
- Controlsn = 10reference
- Outcome
- Exercise ventilatory response (efficiency): V̇E/V̇CO2 slope, PETCO2 and exercise ventilatory inefficiency (EVin) on maximal cardiopulmonary exercise testing
Methodological detailsmatched on age, BMI and body surface area
- Matched on age, BMI and body surface area
Main finding
As reported in the abstract
Exercise ventilatory efficiency
- No correlations between ventilatory inefficiency and biochemical or clinical variables
- Acromegaly vs Controls: P = 0.018
- Acromegaly vs Controls: P = 0.008
- Acromegaly vs Controls: P = 0.019
Observational data: associations, not effects.
Further findings
Peak V̇O2 · peak exercise · lower with acromegaly
P = 0.033
Peak V̇O2 · peak exercise
- Lower peak power output with acromegaly
Lung function and breathing patterns
- No lung function alterations in either group; breathing patterns similar to controls
Original publication
Exercise ventilatory inefficiency may be a specific feature of patients with acromegaly. Pituitary. Published 16 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →